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There are a number of things you can do to manage the side effects of hydroxyureaTalk to your care team about these recommendationsThey can help you decide what will work best for youThese are some of the most common or important side effects:
Bone marrow suppressiondrop in white blood cellred blood cell and platelet countsanorexianauseavomitingdiarrheaconstipationsores in the mouthskin rashswelling in the handsfeetlegs and facechanges in skin pigmentationhair losspainful urinationdrowsinessheadachedizzinessdisorientationhallucinationsseizuresliver problemsshortness of breathmetabolic disturbancesand kidney problems.
For women who are breastfeedingHydroxyurea may pass into breast milk and cause side effects in a child who is breastfedYou should stop breastfeeding when you are taking hydroxyureaTalk to your doctor if you breastfeed your child.
Hydroxyurea causes severe myelosuppressionTreatment with hydroxyurea should not be initiated if bone marrow function is markedly depressedBone marrow suppression may occurand leukopenia is generally its first and most common manifestationThrombocytopenia and anemia occur less often and are seldom seen without a preceding leukopeniaBone marrow depression is more likely in patients who have previously received radiotherapy or cytotoxic cancer chemotherapeutic agentsuse hydroxyurea cautiously in such patients.
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