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Toicoxib is xctd in th milk lactating ats at concntations appoximatly two-old thos in plasma. Th was a dcas in pup body wight ollowing xposu pups tmilk om dams administd toicoxib duing lactation.
Th dcision tpscib a slctiv COX-2 inhibitshould b basd on an assssmnt th individual patint’s ovall isks (s sctions 4.3, 4.4).
Th body poducs twsimila nzyms calld COX-1 and COX-2. COX-1, among oth unctions, is involvd with potcting th stomach, whil COX-2 plays a ol in joint inlammation and pain.
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warfarina en pacientes estabilizados bajo tratamiento cr nico con warfarina, la administraci n de 120 mg diarios de arcoxia se asoci con un aumento de 13 aproximadamente de la proporci n normalizada internacional del tiempo de protrombina.