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MAOs are widely distributed throughout the bodytheir concentration is especially high in liverkidneystomachintestinal walland brainMAOs are currently subclassified into two typesA and Bwhich differ in their substrate specificity and tissue distributionIn humansintestinal MAO is predominantly type Awhile most of that in brain is type B.
The addition of selegiline to levodopa may not be beneficial in those patients who experience fluctuations in response which are not dose dependent.
If you are also taking levodopayou may experience more side effects from the levodopa when taking selegilineTell your doctor right away if any of these side effects occurnauseashakinessmuscle stiffnessmental/mood changes such as hallucinations/abnormal dreamsYour doctor may need to change your medication or doseDo not stop or change the dose of your levodopa without talking with your doctor first.
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