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During concomitant use of CELEBREX and ACE-inhibitorsARBsor beta-blockersmonitor blood pressure to ensure that the desired blood pressure is obtainedDuring concomitant use of CELEBREX and ACE-inhibitors or ARBs in patients who are elderlyvolume-depletedor have impaired renal functionmonitor for signs of worsening renal functionsee WARNINGS AND PRECAUTIONSWhen these drugs are administered concomitantlypatients should be adequately hydratedAssess renal function at the beginning of the concomitant treatment How to buy tegretol online and periodically thereafter.

Read all patient informationmedication guidesand instruction sheets provided to youAsk your doctor or pharmacist if you have any questions.

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Cardiovascular safety was evaluated in two randomizeddouble-blindplacebo-controlledthree year studies involving patients with Sporadic Adenomatous Polyps treated with CELEBREXthe APC trialAdenoma Prevention with Celecoxiband the PreSAP trialPrevention of Spontaneous Adenomatous PolypsIn the APC trialthere was a dose-related increase in the composite endpointadjudicatedof cardiovascular deathmyocardial infarctionor stroke with celecoxib compared to placebo over 3 years of treatmentThe PreSAP trial did not demonstrate a statistically significant increased risk for the same composite endpointadjudicated

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celebrex was shown to be superior to placebo in these studies, using the acr20 responder index, a composite of clinical, laboratory, and functional measures in ra.