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In both trialsoverall survivaltime to progression and response ratecomplete plus partial responseswere assessedResponses were defined by the World Health Organization criteria and submitted to a blinded independent review committeeIRCDifferences in assessments between the investigator and IRC were reconciled by the sponsorblinded to treatment armaccording to a specified algorithmSurvival was assessed based on a non-inferiority analysis.
Additional informationXeloda is in an inactive form when you take itYour liverand then enzymes in the cancer cellsconvert it to its active cancer-fighting form5-fluorouracilCancer cells contain high levels of an enzyme that converts Xeloda to its active stateThis two-step activation process means that a higher concentration of the medicine ends up in the cancer tissuerather than in healthy tissue.
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