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In patients with non-valvular AF that is persistent or paroxysmal and at high risk of strokei.ehaving any of the following featuresprior ischemic stroketransient ischemic attackor systemic embolismor 2 of the following risk factorsage greater than 75 yearsmoderately or Purchase feldene gel severely impaired left ventricularsystolic function and/or heart failurehistory of hypertensionor diabetes mellituslong-term anticoagulation with warfarin is recommendedIn patients with non-valvular AF that is persistent or paroxysmal and at an intermediate risk of ischemic strokei.ehaving 1 of the following risk factorsage greater than 75 yearsmoderately or severely impaired left ventricular systolic function and/or heart failurehistory of hypertensionor diabetes mellituslong-term anticoagulation with warfarin is recommendedFor patients with AF and mitral stenosislong-term anticoagulation with warfarin is recommendedFor patients with AF and prostheticheart valveslong-term anticoagulation with warfarin is recommendedthe target INR may be increased and aspirin added depending on valve type and positionand on patient factors.

Coumadin is used to treat or prevent blood clots in veins or arterieswhich can reduce the risk of strokeheart attackor other serious conditions.

As with most drugsat room temperatureaway from extreme coldheatlightand moisture is bestBathroom cabinets are usually NOT a good place for storing medications because of dampness.

Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.

Examples of drugs known to increase the risk of bleeding are presented in Table 3Because bleeding risk is increased when these drugs are used concomitantly with warfarinclosely monitor patients receiving any such drug with warfarin.

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