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Orally administered Hytrin is indicated in adults for the treatment of mild to moderate hypertensionIt may be used in combination with thiazide diuretics and/or other antihypertensive drugs or as sole therapy where other agents are inappropriate or ineffectiveThe hypotensive effect is most pronounced on the diastolic pressureAlthough the exact mechanism of the hypotensive action of terazosin is not establishedthe relaxation of peripheral blood vessels appears to be produced mainly by competitive antagonism of post-synaptic alpha-1-adrenoceptorsHytrin usually produces an initial gradual decrease in blood pressure followed by a sustained antihypertensive action.
Cardiovascular support is of first importanceRestoration of blood pressure and normalisation of heart rate may be accomplished by keeping the patient in a supine positionIf this measure is inadequateshock should first be treated with volume expanders and if necessaryvasopressors could then be usedRenal function should be monitored and general supportive measures applied as requiredDialysis may not be of benefit since laboratory data indicate that terazosin is highly protein bound.
Due to the vasodilatory effect of terazosinit should be administered with caution if the following cardiac conditions are present:
Hytrin may Aldactone purchase impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.
Hytrin was devoid of mutagenic potential when evaluated in vivo and in vitrothe Ames testin vivo cytogeneticsthe dominant lethal test in micein vivo Chinese hamster chromosome aberration test and V79 forward mutation assay
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